Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha.

• Main Authors: Justin Komguep Nono (Author), Hlumani Ndlovu (Author), Nada Abdel Aziz (Author), Thabo Mpotje (Author), Lerato Hlaka (Author), Frank Brombacher (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin-4 receptor (IL-4Rα) is critical for the initiation of type-2 immune responses and implicated in the pathogenesis of experimental schistosomiasis. IL-4Rα mediated type-2 responses are critical for the control of pathology during acute schistosomiasis. However, type-2 responses tightly ass...