AIRE deficiency, from preclinical models to human APECED disease

• Main Authors: Marine Besnard (Author), Francine Padonou (Author), Nathan Provin (Author), Matthieu Giraud (Author), Carole Guillonneau (Author)
• Format: Book
• Published: The Company of Biologists, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare life-threatening autoimmune disease that attacks multiple organs and has its onset in childhood. It is an inherited condition caused by a variety of mutations in the autoimmune regulator (AIRE) gene that encodes a prot...