Renal toxicity of ifosfamide in children with cancer: an exploratory study integrating aldehyde dehydrogenase enzymatic activity data and a wide-array urinary metabolomics approach

• Päätekijät: Olivia Febvey-Combes (Tekijä), Jérôme Guitton (Tekijä), Perrine Marec-Berard (Tekijä), Cécile Faure-Conter (Tekijä), Ellen Blanc (Tekijä), Sylvie Chabaud (Tekijä), Agnès Conjard-Duplany (Tekijä), Matthias Schell (Tekijä), Laurence Derain Dubourg (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: BMC, 2024-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract Background Ifosfamide is a major anti-cancer drug in children with well-known renal toxicity. Understanding the mechanisms underlying this toxicity could help identify children at increased risk of toxicity. Methods The IFOS01 study included children undergoing ifosfamide-based chemotherapy...