Renal toxicity of ifosfamide in children with cancer: an exploratory study integrating aldehyde dehydrogenase enzymatic activity data and a wide-array urinary metabolomics approach

• Main Authors: Olivia Febvey-Combes (Author), Jérôme Guitton (Author), Perrine Marec-Berard (Author), Cécile Faure-Conter (Author), Ellen Blanc (Author), Sylvie Chabaud (Author), Agnès Conjard-Duplany (Author), Matthias Schell (Author), Laurence Derain Dubourg (Author)
• Format: Book
• Published: BMC, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ifosfamide is a major anti-cancer drug in children with well-known renal toxicity. Understanding the mechanisms underlying this toxicity could help identify children at increased risk of toxicity. Methods The IFOS01 study included children undergoing ifosfamide-based chemotherapy...