HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.

• المؤلفون الرئيسيون: María G Alvarez (مؤلف), Miriam Postan (مؤلف), D Brent Weatherly (مؤلف), María C Albareda (مؤلف), John Sidney (مؤلف), Alessandro Sette (مؤلف), Carina Olivera (مؤلف), Alejandro H Armenti (مؤلف), Rick L Tarleton (مؤلف), Susana A Laucella (مؤلف)
• التنسيق: كتاب
• منشور في: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

BACKGROUND:Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. METHODS AND FINDINGS:Herein, we report the identification of peptides encoded by the same trans-sialidase gene...