HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.

• Hauptverfasser: María G Alvarez (Verfasst von), Miriam Postan (Verfasst von), D Brent Weatherly (Verfasst von), María C Albareda (Verfasst von), John Sidney (Verfasst von), Alessandro Sette (Verfasst von), Carina Olivera (Verfasst von), Alejandro H Armenti (Verfasst von), Rick L Tarleton (Verfasst von), Susana A Laucella (Verfasst von)
• Format: Buch
• Veröffentlicht: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

BACKGROUND:Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. METHODS AND FINDINGS:Herein, we report the identification of peptides encoded by the same trans-sialidase gene...