HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.

• Autori principali: María G Alvarez (Autore), Miriam Postan (Autore), D Brent Weatherly (Autore), María C Albareda (Autore), John Sidney (Autore), Alessandro Sette (Autore), Carina Olivera (Autore), Alejandro H Armenti (Autore), Rick L Tarleton (Autore), Susana A Laucella (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

BACKGROUND:Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. METHODS AND FINDINGS:Herein, we report the identification of peptides encoded by the same trans-sialidase gene...