HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.

• Principais autores: María G Alvarez (Autor), Miriam Postan (Autor), D Brent Weatherly (Autor), María C Albareda (Autor), John Sidney (Autor), Alessandro Sette (Autor), Carina Olivera (Autor), Alejandro H Armenti (Autor), Rick L Tarleton (Autor), Susana A Laucella (Autor)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BACKGROUND:Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. METHODS AND FINDINGS:Herein, we report the identification of peptides encoded by the same trans-sialidase gene...