Preparation, characterization, and in vitro/vivo evaluation of polymer-assisting formulation of atorvastatin calcium based on solid dispersion technique

• Main Authors: Wenxiang Dong (Author), Xitong Su (Author), Meng Xu (Author), Mingming Hu (Author), Yinghua Sun (Author), Peng Zhang (Author)
• פורמט: ספר
• יצא לאור: Elsevier, 2018-11-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Due to low solubility and bioavailability, atorvastatin calcium is confronted with challenge in conceiving appropriate formulation. Solid dispersion of atorvastatin calcium was prepared through the solvent evaporation method, with Poloxamer 188 as hydrophilic carriers. This formulation was then char...