Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels

• Glavni autori: Peiwen Li (Autor), Xiaohui Tian (Autor), Gongxin Wang (Autor), Enshe Jiang (Autor), Yanming Li (Autor), Guoliang Hao (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Introduction: As the third generation of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), osimertinib has demonstrated more significant cardiotoxicity than previous generations of EGFR-TKIs. Investigating the mechanism of osimertinib cardiotoxicity can provide a reference for a...