Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels

• 主要な著者: Peiwen Li (著者), Xiaohui Tian (著者), Gongxin Wang (著者), Enshe Jiang (著者), Yanming Li (著者), Guoliang Hao (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Introduction: As the third generation of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), osimertinib has demonstrated more significant cardiotoxicity than previous generations of EGFR-TKIs. Investigating the mechanism of osimertinib cardiotoxicity can provide a reference for a...