Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels

• Egile Nagusiak: Peiwen Li (Egilea), Xiaohui Tian (Egilea), Gongxin Wang (Egilea), Enshe Jiang (Egilea), Yanming Li (Egilea), Guoliang Hao (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Introduction: As the third generation of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), osimertinib has demonstrated more significant cardiotoxicity than previous generations of EGFR-TKIs. Investigating the mechanism of osimertinib cardiotoxicity can provide a reference for a...