Experimental osteonecrosis: development of a model in rodents administered alendronate

• Principais autores: Nicolau CONTE NETO (Autor), Luis Carlos SPOLIDORIO (Autor), Cleverton Roberto de ANDRADE (Autor), Jônatas Caldeira ESTEVES (Autor), Elcio MARCANTONIO JR (Autor)
• Formato: Livro
• Publicado em: Sociedade Brasileira de Pesquisa Odontológica.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract The main objective of this study was to cause bisphosphonate-related osteonecrosis of the jaws to develop in a rodent model. Adult male Holtzman rats were assigned to one of two experimental groups to receive alendronate (AL; 1 mg/kg/week; n = 6) or saline solution (CTL; n = 6). After 60 da...