Identification of novel PD-1/PD-L1 small molecule inhibitors: virtual screening, synthesis and in vitro characterisation

• Main Authors: Tingting Wu (Author), Hu Cheng (Author), Lijie Sima (Author), Zhongyuan Wang (Author), Weiwei Ouyang (Author), Jianta Wang (Author), Yunlei Hou (Author), Dongsheng Zhao (Author), Weike Liao (Author), Chujiao Hu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The PD-1/PD-L1 pathway is considered as one of the most promising immune checkpoints in tumour immunotherapy. However, researchers are faced with the inherent limitations of antibodies, driving them to pursue PD-L1 small molecule inhibitors. Virtual screening followed by experimental validation is a...