Identification of novel PD-1/PD-L1 small molecule inhibitors: virtual screening, synthesis and in vitro characterisation

• Main Authors: Tingting Wu (Author), Hu Cheng (Author), Lijie Sima (Author), Zhongyuan Wang (Author), Weiwei Ouyang (Author), Jianta Wang (Author), Yunlei Hou (Author), Dongsheng Zhao (Author), Weike Liao (Author), Chujiao Hu (Author)
• Format: Bog
• Udgivet: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Fag: article
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The PD-1/PD-L1 pathway is considered as one of the most promising immune checkpoints in tumour immunotherapy. However, researchers are faced with the inherent limitations of antibodies, driving them to pursue PD-L1 small molecule inhibitors. Virtual screening followed by experimental validation is a...