Identification of novel PD-1/PD-L1 small molecule inhibitors: virtual screening, synthesis and in vitro characterisation

• 主要な著者: Tingting Wu (著者), Hu Cheng (著者), Lijie Sima (著者), Zhongyuan Wang (著者), Weiwei Ouyang (著者), Jianta Wang (著者), Yunlei Hou (著者), Dongsheng Zhao (著者), Weike Liao (著者), Chujiao Hu (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The PD-1/PD-L1 pathway is considered as one of the most promising immune checkpoints in tumour immunotherapy. However, researchers are faced with the inherent limitations of antibodies, driving them to pursue PD-L1 small molecule inhibitors. Virtual screening followed by experimental validation is a...