Comparison of Two Mice Strains, A/J and C57BL/6, in Caspase-1 Activity and IL-1β Secretion of Macrophage to Mycobacterium leprae Infection

• Glavni autori: Tae Jin Kang (Autor), Geum Seon Lee (Autor), Se Kon Kim (Autor), Song Hou Jin (Autor), Gue Tae Chae (Autor)
• Format: Knjiga
• Izdano: Hindawi Limited, 2010-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

A/J mice were found to have amino acid differences in Naip5, one of the NOD-like receptors (NLRs) involved in the cytosolic recognition of pathogen-associated molecular patterns and one of the adaptor proteins for caspase-1 activation. This defect was associated with a susceptibility to Legionella i...