Engineering miniature CRISPR-Cas Un1Cas12f1 for efficient base editing
Adeno-associated virus (AAV) is a relatively safe and efficient vector for gene therapy. However, due to its 4.7-kb limit of cargo, SpCas9-mediated base editors cannot be packaged into a single AAV vector, which hinders their clinical application. The development of efficient miniature base editors...
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| Main Authors: | , , , , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2024-06-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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