Bisacodyl overcomes morphine-induced constipation by decreasing colonic Aquaporin-3 and Aquaporin-4 expression

• Main Authors: Mahardian Rahmadi (Author), Chrismawan Ardianto (Author), Ahmad D. Nurhan (Author), Rafiqa A. Chasanah (Author), Dewi I. Krismonika (Author), Arina D. Puspitasari (Author), Budi Suprapti (Author), Santhra Segaran (Author), Chia-Wei Phan (Author), Junaidi Khotib (Author)
• Format: Book
• Published: Belgorod National Research University, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Morphine is an opioid prescribed to treat aches and pains. However, morphine often causes opioid-induced constipation (OIC). Aquaporin (AQP) transporters, especially AQP3 and AQP4, play an essential role in mediating constipation. Bisacodyl is a common laxative used to treat constipati...