Bisacodyl overcomes morphine-induced constipation by decreasing colonic Aquaporin-3 and Aquaporin-4 expression

• Главные авторы: Mahardian Rahmadi (Автор), Chrismawan Ardianto (Автор), Ahmad D. Nurhan (Автор), Rafiqa A. Chasanah (Автор), Dewi I. Krismonika (Автор), Arina D. Puspitasari (Автор), Budi Suprapti (Автор), Santhra Segaran (Автор), Chia-Wei Phan (Автор), Junaidi Khotib (Автор)
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• Опубликовано: Belgorod National Research University, 2022-11-01T00:00:00Z.
• Предметы: article
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Introduction: Morphine is an opioid prescribed to treat aches and pains. However, morphine often causes opioid-induced constipation (OIC). Aquaporin (AQP) transporters, especially AQP3 and AQP4, play an essential role in mediating constipation. Bisacodyl is a common laxative used to treat constipati...