UPLC-MS/MS method for simultaneously determining nucleosides and methyl-nucleosides in liver mRNA of Epimedin C-induced liver injury mouse model

• Autori principali: Zhizhen Song (Autore), Zeyun Li (Autore), Xueqian Wen (Autore), Ruijuan Liu (Autore), Xin Tian (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2021-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background Epimedin C, one of the main active ingredients of Epimedium, has been reported to have potential hepatotoxicity. However, the mechanism of Epimedin C-induced liver injury has not been studied. mRNA methylation, mainly including N6-methyladenosine and N5-methylcytidine, is implica...