Involvement of neuronal nitric oxide synthase in N-methyl-N-nitrosourea-induced retinal degeneration in mice

• Main Authors: Yoshiki Koriyama (Author), Suguru Hisano (Author), Kazuhiro Ogai (Author), Kayo Sugitani (Author), Ayako Furukawa (Author), Satoru Kato (Author)
• Format: Book
• Published: Elsevier, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

N-methyl-N-nitrosourea (MNU) is widely used to study the mechanism of retinal degenerative diseases (RDs) because of its selectivity of photoreceptor cell death. Many reports suggest that excessive nitric oxide (NO) plays a crucial role in neuronal cell death. We hypothesized that nitric oxide synth...