Involvement of neuronal nitric oxide synthase in N-methyl-N-nitrosourea-induced retinal degeneration in mice

• Principais autores: Yoshiki Koriyama (Autor), Suguru Hisano (Autor), Kazuhiro Ogai (Autor), Kayo Sugitani (Autor), Ayako Furukawa (Autor), Satoru Kato (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2015-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

N-methyl-N-nitrosourea (MNU) is widely used to study the mechanism of retinal degenerative diseases (RDs) because of its selectivity of photoreceptor cell death. Many reports suggest that excessive nitric oxide (NO) plays a crucial role in neuronal cell death. We hypothesized that nitric oxide synth...