Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

• Hoofdauteurs: Chao-Yuan Chang (Auteur), Kung-Yen Chen (Auteur), Hung-Jen Shih (Auteur), Milton Chiang (Auteur), I-Tao Huang (Auteur), Yen-Hua Huang (Auteur), Chun-Jen Huang (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2021-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Obesity complicates sepsis and increases the mortality of sepsis. We examined the effects of exosomes (from human placenta choriodecidual membrane-derived mesenchymal stem cells, pcMSCs) on preventing sepsis in obesity and the mitigating role of hsa-let-7i-5p microRNA. Obese mice (adult male C57BL/6...