Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

• Главные авторы: Chao-Yuan Chang (Автор), Kung-Yen Chen (Автор), Hung-Jen Shih (Автор), Milton Chiang (Автор), I-Tao Huang (Автор), Yen-Hua Huang (Автор), Chun-Jen Huang (Автор)
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• Опубликовано: MDPI AG, 2021-12-01T00:00:00Z.
• Предметы: article
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Obesity complicates sepsis and increases the mortality of sepsis. We examined the effects of exosomes (from human placenta choriodecidual membrane-derived mesenchymal stem cells, pcMSCs) on preventing sepsis in obesity and the mitigating role of hsa-let-7i-5p microRNA. Obese mice (adult male C57BL/6...