Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

• Glavni autori: Chao-Yuan Chang (Autor), Kung-Yen Chen (Autor), Hung-Jen Shih (Autor), Milton Chiang (Autor), I-Tao Huang (Autor), Yen-Hua Huang (Autor), Chun-Jen Huang (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Obesity complicates sepsis and increases the mortality of sepsis. We examined the effects of exosomes (from human placenta choriodecidual membrane-derived mesenchymal stem cells, pcMSCs) on preventing sepsis in obesity and the mitigating role of hsa-let-7i-5p microRNA. Obese mice (adult male C57BL/6...