An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesis

• Váldodahkkit: Gulcan Semra Sahin (Dahkki), Hugo Lee (Dahkki), Feyza Engin (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2021-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Background: Pancreatic β-cells are the insulin factory of an organism with a mission to regulate glucose homeostasis in the body. Due to their high secretory activity, β-cells rely on a functional and intact endoplasmic reticulum (ER). Perturbations to ER homeostasis and unmitigated stress lead to β...