Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis

• প্রধান লেখক: Hongwei Shi (লেখক), Heng Tang (লেখক), Wen Ai (লেখক), Qingfu Zeng (লেখক), Hong Yang (লেখক), Fengqing Zhu (লেখক), Yunjie Wei (লেখক), Rui Feng (লেখক), Li Wen (লেখক), Peng Pu (লেখক), Quan He (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Objective: Pirarubicin (THP), one of the anthracycline anticancer drugs, is widely used in the treatment of various cancers, but its cardiotoxicity cannot be ignored. Schisandrin B (SchB) has the ability to upregulate cellular antioxidant defense mechanism and promote mitochondrial function and anti...