Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis

• Main Authors: Hongwei Shi (Author), Heng Tang (Author), Wen Ai (Author), Qingfu Zeng (Author), Hong Yang (Author), Fengqing Zhu (Author), Yunjie Wei (Author), Rui Feng (Author), Li Wen (Author), Peng Pu (Author), Quan He (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Pirarubicin (THP), one of the anthracycline anticancer drugs, is widely used in the treatment of various cancers, but its cardiotoxicity cannot be ignored. Schisandrin B (SchB) has the ability to upregulate cellular antioxidant defense mechanism and promote mitochondrial function and anti...