Development of Non-Ethoxypropanoic Acid Type Cryptochrome Inhibitors with Circadian Molecular Clock-Enhancing Activity by Bioisosteric Replacement

• Main Authors: Yong Uk Jeong (Author), Hyo-Eon Jin (Author), Hye Young Lim (Author), Goyeong Choi (Author), Hansol Joo (Author), Bohun Kang (Author), Ga-Hyun Lee (Author), Kwang-Hyeon Liu (Author), Han-Joo Maeng (Author), Sooyoung Chung (Author), Gi Hoon Son (Author), Jong-Wha Jung (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Circadian dysfunction is closely associated with an increased risk of various diseases. Considering that molecular clock machinery serves as an intrinsic time-keeping system underlying the circadian rhythm of biological processes, the modulation of the molecular clock machinery is an attractive ther...