Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood

• मुख्य लेखकों: Shuzhen Chen (लेखक), Yaping Dong (लेखक), Xinming Qi (लेखक), Qiqi Cao (लेखक), Tao Luo (लेखक), Zhaofang Bai (लेखक), Huisi He (लेखक), Zhecai Fan (लेखक), Lingyan Xu (लेखक), Guozhen Xing (लेखक), Chunyu Wang (लेखक), Zhichao Jin (लेखक), Zhixuan Li (लेखक), Lei Chen (लेखक), Yishan Zhong (लेखक), Jiao Wang (लेखक), Jia Ge (लेखक), Xiaohe Xiao (लेखक), Xiuwu Bian (लेखक), Wen Wen (लेखक), Jin Ren (लेखक), Hongyang Wang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Aristolochic acids (AAs) have long been considered as a potent carcinogen due to its nephrotoxicity. Aristolochic acid I (AAI) reacts with DNA to form covalent aristolactam (AL)-DNA adducts, leading to subsequent A to T transversion mutation, commonly referred as AA mutational signature. Previous re...