Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood

• Main Authors: Shuzhen Chen (Author), Yaping Dong (Author), Xinming Qi (Author), Qiqi Cao (Author), Tao Luo (Author), Zhaofang Bai (Author), Huisi He (Author), Zhecai Fan (Author), Lingyan Xu (Author), Guozhen Xing (Author), Chunyu Wang (Author), Zhichao Jin (Author), Zhixuan Li (Author), Lei Chen (Author), Yishan Zhong (Author), Jiao Wang (Author), Jia Ge (Author), Xiaohe Xiao (Author), Xiuwu Bian (Author), Wen Wen (Author), Jin Ren (Author), Hongyang Wang (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aristolochic acids (AAs) have long been considered as a potent carcinogen due to its nephrotoxicity. Aristolochic acid I (AAI) reacts with DNA to form covalent aristolactam (AL)-DNA adducts, leading to subsequent A to T transversion mutation, commonly referred as AA mutational signature. Previous re...