Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants

• Main Authors: Viggo G. Blomquist (Author), Jacqueline Niu (Author), Papiya Choudhury (Author), Ahmad Al Saneh (Author), Henry M. Colecraft (Author), Christopher A. Ahern (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Disease-causing premature termination codons (PTCs) individually disrupt the functional expression of hundreds of genes and represent a pernicious clinical challenge. In the heart, loss-of-function mutations in the hERG potassium channel account for approximately 30% of long-QT syndrome arrhythmia,...