Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants

• Hoofdauteurs: Viggo G. Blomquist (Auteur), Jacqueline Niu (Auteur), Papiya Choudhury (Auteur), Ahmad Al Saneh (Auteur), Henry M. Colecraft (Auteur), Christopher A. Ahern (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2023-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Disease-causing premature termination codons (PTCs) individually disrupt the functional expression of hundreds of genes and represent a pernicious clinical challenge. In the heart, loss-of-function mutations in the hERG potassium channel account for approximately 30% of long-QT syndrome arrhythmia,...