FTO is necessary for the induction of leptin resistance by high-fat feeding

• Main Authors: Y.C. Loraine Tung (Author), Pawan Gulati (Author), Che-Hsiung Liu (Author), Debra Rimmington (Author), Rowena Dennis (Author), Marcella Ma (Author), Vladimir Saudek (Author), Stephen O'Rahilly (Author), Anthony P. Coll (Author), Giles S.H. Yeo (Author)
• Format: Book
• Published: Elsevier, 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Loss of function FTO mutations significantly impact body composition in humans and mice, with Fto-deficient mice reported to resist the development of obesity in response to a high-fat diet (HFD). We aimed to further explore the interactions between FTO and HFD and determine if FTO can in...