FTO is necessary for the induction of leptin resistance by high-fat feeding

• मुख्य लेखकों: Y.C. Loraine Tung (लेखक), Pawan Gulati (लेखक), Che-Hsiung Liu (लेखक), Debra Rimmington (लेखक), Rowena Dennis (लेखक), Marcella Ma (लेखक), Vladimir Saudek (लेखक), Stephen O'Rahilly (लेखक), Anthony P. Coll (लेखक), Giles S.H. Yeo (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2015-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Loss of function FTO mutations significantly impact body composition in humans and mice, with Fto-deficient mice reported to resist the development of obesity in response to a high-fat diet (HFD). We aimed to further explore the interactions between FTO and HFD and determine if FTO can in...