FTO is necessary for the induction of leptin resistance by high-fat feeding

• Váldodahkkit: Y.C. Loraine Tung (Dahkki), Pawan Gulati (Dahkki), Che-Hsiung Liu (Dahkki), Debra Rimmington (Dahkki), Rowena Dennis (Dahkki), Marcella Ma (Dahkki), Vladimir Saudek (Dahkki), Stephen O'Rahilly (Dahkki), Anthony P. Coll (Dahkki), Giles S.H. Yeo (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2015-04-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Objective: Loss of function FTO mutations significantly impact body composition in humans and mice, with Fto-deficient mice reported to resist the development of obesity in response to a high-fat diet (HFD). We aimed to further explore the interactions between FTO and HFD and determine if FTO can in...