Species comparison of pre-systemic bioactivation of vicagrel, a new acetate derivative of clopidogrel

• Main Authors: Zhi xia Qiu (Author), Wen Chao Gao (Author), Yu Dai (Author), Su feng Zhou (Author), Jie Zhao (Author), Yang Lu (Author), Xi jing Chen (Author), Ning Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previously we have found vicagrel, a new acetate derivative of clopidogrel, underwent hydrolysis to 2-oxo-clopidogrel and subsequent conversions to its pharmacological active metabolite (AM) and inactive carboxylic acid metabolite (CAM). This study demonstrated the interspecies differences of the vi...