Species comparison of pre-systemic bioactivation of vicagrel, a new acetate derivative of clopidogrel

• Prif Awduron: Zhi xia Qiu (Awdur), Wen Chao Gao (Awdur), Yu Dai (Awdur), Su feng Zhou (Awdur), Jie Zhao (Awdur), Yang Lu (Awdur), Xi jing Chen (Awdur), Ning Li (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Previously we have found vicagrel, a new acetate derivative of clopidogrel, underwent hydrolysis to 2-oxo-clopidogrel and subsequent conversions to its pharmacological active metabolite (AM) and inactive carboxylic acid metabolite (CAM). This study demonstrated the interspecies differences of the vi...