Species comparison of pre-systemic bioactivation of vicagrel, a new acetate derivative of clopidogrel

• Hoofdauteurs: Zhi xia Qiu (Auteur), Wen Chao Gao (Auteur), Yu Dai (Auteur), Su feng Zhou (Auteur), Jie Zhao (Auteur), Yang Lu (Auteur), Xi jing Chen (Auteur), Ning Li (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Previously we have found vicagrel, a new acetate derivative of clopidogrel, underwent hydrolysis to 2-oxo-clopidogrel and subsequent conversions to its pharmacological active metabolite (AM) and inactive carboxylic acid metabolite (CAM). This study demonstrated the interspecies differences of the vi...