Estradiol inhibits phosphorylation of JAK/STAT, PI3K/AKT and expression of IL-17A in mouse mononuclear cells treated with IL-36β

• Main Authors: Shuang LIU (Author), Shanshan YANG (Author), Chunchan ZHENG (Author), Sujun LUO (Author), Na WEI (Author), Sirui LI (Author), Jianqiang SHI (Author), Rongyi CHEN (Author)
• Format: Book
• Published: editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective To investigate the effects of β-estradiol (E2) on the phosphorylation of JAK/STAT, PI3K/AKT signaling pathways and the expression of IL-17A in mouse spleen mononuclear cells treated with IL-36β. Methods The spleens were isolated from female SPF C57BL/6 mice aged 6-8 weeks. The mononuclear...