Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer's disease

Glycogen synthase kinase 3β (GSK-3β) catalyses the hyperphosphorylation of tau protein in the Alzheimer's disease (AD) pathology. A series of novel thieno[3,2-c]pyrazol-3-amine derivatives were designed and synthesised and evaluated as potential GSK-3β inhibitors by structure-guided drug ration...

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ग्रंथसूची विवरण
मुख्य लेखकों: Ning Yan (लेखक), Xiao-Long Shi (लेखक), Long-Qian Tang (लेखक), De-Feng Wang (लेखक), Xun Li (लेखक), Chao Liu (लेखक), Zhao-Peng Liu (लेखक)
स्वरूप: पुस्तक
प्रकाशित: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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