Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer's disease

• Hoofdauteurs: Ning Yan (Auteur), Xiao-Long Shi (Auteur), Long-Qian Tang (Auteur), De-Feng Wang (Auteur), Xun Li (Auteur), Chao Liu (Auteur), Zhao-Peng Liu (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Glycogen synthase kinase 3β (GSK-3β) catalyses the hyperphosphorylation of tau protein in the Alzheimer's disease (AD) pathology. A series of novel thieno[3,2-c]pyrazol-3-amine derivatives were designed and synthesised and evaluated as potential GSK-3β inhibitors by structure-guided drug ration...