Trypanosoma cruzi-specific IFN-γ-producing cells in chronic Chagas disease associate with a functional IL-7/IL-7R axis.

• Autori principali: María A Natale (Autore), Gonzalo Cesar (Autore), María G Alvarez (Autore), Melisa D Castro Eiro (Autore), Bruno Lococo (Autore), Graciela Bertocchi (Autore), María C Albareda (Autore), Susana A Laucella (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2018-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

<h4>Background</h4>The severity of cardiac disease in chronic Chagas disease patients is associated with different features of T-cell exhaustion. Here, we assessed whether the ability of T cells to secrete IFN-γ in response to T. cruzi was linked to disruption in immune homeostasis and i...