TGF-Beta Blockade Increases Renal Inflammation Caused by the C-Terminal Module of the CCN2

• Main Authors: Raquel Rodrigues-Díez (Author), Sandra Rayego-Mateos (Author), Macarena Orejudo (Author), Luiz Stark Aroeira (Author), Rafael Selgas (Author), Alberto Ortiz (Author), Jesús Egido (Author), Marta Ruiz-Ortega (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The CCN family member 2 (CCN2, also known as connective tissue growth factor) may behave as a risk biomarker and a potential therapeutic target for renal disease. CCN2 participates in the regulation of inflammation and fibrosis. TGF-β is considered the main fibrogenic cytokine; however, in some path...