Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide

• Main Authors: Ali Fattahi (Author), Mansoureh Ghiasi (Author), Pardis Mohammadi (Author), Leila Hosseinzadeh (Author), Khosro Adibkia (Author), Ghobad Mohammadi (Author)
• Format: Book
• Published: Universidade de São Paulo, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L-lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The struct...