Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide

• Автори: Ali Fattahi (Автор), Mansoureh Ghiasi (Автор), Pardis Mohammadi (Автор), Leila Hosseinzadeh (Автор), Khosro Adibkia (Автор), Ghobad Mohammadi (Автор)
• Формат: Книга
• Опубліковано: Universidade de São Paulo, 2019-04-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L-lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The struct...