Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide

• Glavni autori: Ali Fattahi (Autor), Mansoureh Ghiasi (Autor), Pardis Mohammadi (Autor), Leila Hosseinzadeh (Autor), Khosro Adibkia (Autor), Ghobad Mohammadi (Autor)
• Format: Knjiga
• Izdano: Universidade de São Paulo, 2019-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L-lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The struct...