Drug Discovery of DKK1 Inhibitors

• Main Authors: Hewen Jiang (Author), Zongkang Zhang (Author), Yuanyuan Yu (Author), Hang Yin Chu (Author), Sifan Yu (Author), Shanshan Yao (Author), Ge Zhang (Author), Bao-Ting Zhang (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Fag: article
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Dickkopf-1 (DKK1) is a well-characterized Wnt inhibitor and component of the Wnt/β-catenin signaling pathway, whose dysregulation is associated with multiple abnormal pathologies including osteoporosis, Alzheimer's disease, diabetes, and various cancers. The Wnt signaling pathway has fundamenta...