Repurposing nitrofurantoin as a stimulant of fibroblast extracellular matrix repair for the treatment of emphysema

• Главные авторы: Mathew N. Leslie (Автор), Zara Sheikh (Автор), Dikaia Xenaki (Автор), Brian G. Oliver (Автор), Paul M. Young (Автор), Daniela Traini (Автор), Hui Xin Ong (Автор)
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• Опубликовано: Elsevier, 2024-09-01T00:00:00Z.
• Предметы: article
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Emphysema is a respiratory disease that causes the progressive loss of lung extracellular matrix (ECM) organisation, subsequently undermining lung integrity and reducing lung function. Fibroblasts must constantly repair damage to the lungs to preserve lung health, however, fibroblast ECM repair is r...