Repurposing nitrofurantoin as a stimulant of fibroblast extracellular matrix repair for the treatment of emphysema

• Main Authors: Mathew N. Leslie (Author), Zara Sheikh (Author), Dikaia Xenaki (Author), Brian G. Oliver (Author), Paul M. Young (Author), Daniela Traini (Author), Hui Xin Ong (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Emphysema is a respiratory disease that causes the progressive loss of lung extracellular matrix (ECM) organisation, subsequently undermining lung integrity and reducing lung function. Fibroblasts must constantly repair damage to the lungs to preserve lung health, however, fibroblast ECM repair is r...