Optimization of a Cefuroxime Axetil-Loaded Liquid Self-Nanoemulsifying Drug Delivery System: Enhanced Solubility, Dissolution and Caco-2 Cell Uptake

• Váldodahkkit: Arshad Ali Khan (Dahkki), Akhtar Atiya (Dahkki), Safia Akhtar (Dahkki), Yogesh Yadav (Dahkki), Kamal A. Qureshi (Dahkki), Mariusz Jaremko (Dahkki), Syed Mahmood (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2022-04-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Cefuroxime axetil (CA) is an oral cephalosporin which hydrolyzes rapidly to the active parent compound cefuroxime. CA is known to have incomplete oral bioavailability (30-50%) due to its poor solubility and enzymatic conversion to cefuroxime in the gut lumen. In order to overcome these drawbacks, a...