Optimization of a Cefuroxime Axetil-Loaded Liquid Self-Nanoemulsifying Drug Delivery System: Enhanced Solubility, Dissolution and Caco-2 Cell Uptake

• Principais autores: Arshad Ali Khan (Autor), Akhtar Atiya (Autor), Safia Akhtar (Autor), Yogesh Yadav (Autor), Kamal A. Qureshi (Autor), Mariusz Jaremko (Autor), Syed Mahmood (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2022-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Cefuroxime axetil (CA) is an oral cephalosporin which hydrolyzes rapidly to the active parent compound cefuroxime. CA is known to have incomplete oral bioavailability (30-50%) due to its poor solubility and enzymatic conversion to cefuroxime in the gut lumen. In order to overcome these drawbacks, a...