Pharmacological Validation of ASIC1a as a Druggable Target for Neuroprotection in Cerebral Ischemia Using an Intravenously Available Small Molecule Inhibitor

• 主要な著者: Xin Qi (著者), Jian-Fei Lu (著者), Zi-Yue Huang (著者), Yi-Jun Liu (著者), Lu-Bing Cai (著者), Xin-Lan Wen (著者), Xing-Lei Song (著者), Jian Xiong (著者), Pei-Yi Sun (著者), Hao Zhang (著者), Ting-Ting Zhang (著者), Xuan Zhao (著者), Qin Jiang (著者), Ying Li (著者), Oleg Krishtal (著者), Leng-Chen Hou (著者), Michael X. Zhu (著者), Tian-Le Xu (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Acidosis is a hallmark of ischemic stroke and a promising neuroprotective target for preventing neuronal injury. Previously, genetic manipulations showed that blockade of acid-sensing ion channel 1a (ASIC1a)-mediated acidotoxicity could dramatically alleviate the volume of brain infarct and restore...