Pharmacological Validation of ASIC1a as a Druggable Target for Neuroprotection in Cerebral Ischemia Using an Intravenously Available Small Molecule Inhibitor

• Main Authors: Xin Qi (Author), Jian-Fei Lu (Author), Zi-Yue Huang (Author), Yi-Jun Liu (Author), Lu-Bing Cai (Author), Xin-Lan Wen (Author), Xing-Lei Song (Author), Jian Xiong (Author), Pei-Yi Sun (Author), Hao Zhang (Author), Ting-Ting Zhang (Author), Xuan Zhao (Author), Qin Jiang (Author), Ying Li (Author), Oleg Krishtal (Author), Leng-Chen Hou (Author), Michael X. Zhu (Author), Tian-Le Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acidosis is a hallmark of ischemic stroke and a promising neuroprotective target for preventing neuronal injury. Previously, genetic manipulations showed that blockade of acid-sensing ion channel 1a (ASIC1a)-mediated acidotoxicity could dramatically alleviate the volume of brain infarct and restore...