Bioavailability of a novel sustained‐release pellet formulation of 5‐flucytosine in healthy‐fed participants for use in patients with cryptococcal meningitis

• Main Authors: Nabila Ibnou Zekri Lassout (Author), Vishal Goyal (Author), Edrich Krantz (Author), Francois Simon (Author), Anouk Neven (Author), Johanna Eriksson (Author), Amaria Saayman (Author), Vijay Satam (Author), Carol Ruffell (Author), Sarika Victor (Author), Marylore Chenel (Author), Aljosa Celebic (Author), Henri Caplain (Author), Jean‐Yves Gillon (Author), Abhijit Deshmukh (Author), Amit Antarkar (Author), Eric Sjögren (Author), Isabela Ribeiro (Author)
• Format: Book
• Published: Wiley, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Cryptococcal meningoencephalitis (CM) is an opportunistic fungal infection and a major cause of death among people living with human immunodeficiency virus in sub‐Saharan Africa. 5‐flucytosine (5‐FC) is a unique, brain‐permeable antifungal agent used to reduce mortality from CM and to preve...