Rapid and sensitive analysis of melatonin by LC-MS/MS and its application to pharmacokinetic study in dogs

• मुख्य लेखकों: Huimin Zhao (लेखक), Yifei Wang (लेखक), Yi Jin (लेखक), Shu Liu (लेखक), Haiyan Xu (लेखक), Xiumei Lu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2016-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

A rapid and sensitive liquid chromatography tandem mass spectrometry method was established and validated for determination of melatonin in dog plasma using desvenlafaxine as an internal standard (IS). Plasma samples were pretreated by liquid-liquid extraction with ethyl acetate. Chromatographic sep...